| Enantioselective Separation of Indole Derivatives by Liquid Chromatography Using Immobilized Cellulose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase | |
| Department | 甘肃省天然药物重点实验室 |
Zhao L(赵亮) ; Ming YF(明永飞); Zhang HL(张红丽); Jiang SX(蒋生祥)
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| 2009 | |
| Source Publication | Journal of Analytical Chemistry
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| ISSN | 1061－9348 |
| Volume | 64Issue:8Pages:795-805 |
| Abstract | A new chiral stationary phase of 3,5-dimethylphenylcarbamates of cellulose chemically bonded to 3-aminopropyl silica gel was prepared, which may be used with a wide range of solvents including standard and non-standard ones. Several racemic indole derivatives have been resolved using standard and non-standard solvents on the immobilized chiral column (15 cm×0.46 cm) at a flow rate of 1.0 mL/min or 0.5 mL/min with a UV detection at 230 nm. Separation of indole derivatives on immobilized and coated chiral stationary phases(CSP) in HPLC using a mixture of hexane/2-propanol as mobile phase was compared. The resolution factors for immobilized and coated chiral column were 0.57–2.02 and 0.61–4.03, respectively. It was found that both coated and immbolized chiral stationary phases were suitable for the separation of indole derivatives; however, the coated CSP possesses a higher resolving power than the immobilized one. |
| Subject Area | 分析化学与药物化学 |
| Funding Organization | National Natural Science Foundation of China (No. 20375045,20675085);the Natural Science Foundation of Gansu province (No-3ZS041-A25-23);the Light in Chinese Western Region (2003) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 药物手性分离研究组 ; 药物分离材料研究组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/1191 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Zhao L(赵亮) |
| Recommended Citation GB/T 7714 | Zhao L,Ming YF,Zhang HL,et al. Enantioselective Separation of Indole Derivatives by Liquid Chromatography Using Immobilized Cellulose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase[J]. Journal of Analytical Chemistry,2009,64(8):795-805. |
| APA | 赵亮,明永飞,张红丽,&蒋生祥.(2009).Enantioselective Separation of Indole Derivatives by Liquid Chromatography Using Immobilized Cellulose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase.Journal of Analytical Chemistry,64(8),795-805. |
| MLA | 赵亮,et al."Enantioselective Separation of Indole Derivatives by Liquid Chromatography Using Immobilized Cellulose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase".Journal of Analytical Chemistry 64.8(2009):795-805. |
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