Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode

LICP OpenIR > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode
Department	甘肃省天然药物重点实验室
	Hu GZ(胡广志); Guo Y(郭勇); Shao SJ(邵士俊)
	2009
Source Publication	Biosensors and Bioelectronics
ISSN	0956-5663
Volume	24 Pages:3391-3394
Abstract	A new ordered mesoporous carbon (OMC) modified pyrolytic graphite electrode (PGE) was prepared to investigate electrochemical behavior of the anticancer drug tirapazamine (TPZ). Compared to the bare PGE, themodifiedelectrode showedanexcellent electrochemical response to TPZ. The anodic peak current (Ipa) of TPZ at the OMC/PGE is 180-fold higher than that of the bare PGE. The Ipa is proportional with TPZ concentration in the range of 5.0×10−11 to 1.5×10−5 mol L−1. The linear regression equations are Ipa ( A) = 0.0000044 + 16.928CTPZ ( mol L−1), with a detection limit (S/N = 3) of 2.0×10−11 mol L−1. This proposedmethod can be potentially used for ultrasensitive electrochemical sensing of TPZ inphysiological condition.
Keyword	Ordered Mesoporous Carbon Tirapazamine Electrochemical Sensor Ultrasensitive Determination
Subject Area	分析化学与药物化学
Funding Organization	National Nature Science Foundation of China (No. 20672121)
Indexed By	SCI
Language	英语
Funding Project	药物分子识别研究组
Citation statistics	Cited Times:26[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/1186
Collection	中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
Corresponding Author	Shao SJ(邵士俊)
Recommended Citation GB/T 7714	Hu GZ,Guo Y,Shao SJ. Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode[J]. Biosensors and Bioelectronics,2009,24:3391-3394.
APA	胡广志,郭勇,&邵士俊.(2009).Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode.Biosensors and Bioelectronics,24,3391-3394.
MLA	胡广志,et al."Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode".Biosensors and Bioelectronics 24(2009):3391-3394.

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