| Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium | |
| Department | 环境材料与生态化学研究发展中心 |
Zhang JP(张俊平) ; Wang Q(汪琴); Xie XL(谢小玲); Li X(李迅); Wang AQ(王爱勤); 王爱勤 aqwang@licp.cas.cn
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| 2010 | |
| Source Publication | Journal of Biomedical Materials Research: Part B -Applied Biomaterials
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| ISSN | 1552-4973 |
| Volume | 92Issue:1Pages:205-214 |
| Abstract | Layered double hydroxides (LDHs) are promising materials for the preparation of novel drug delivery matrices. To reveal the interaction between LDHs and polymers, a series of pH-sensitive sodium alginate/layered double hydroxides (SA/LDHs) hybrid beads were prepared using the simple surface crosslinking method. The SA/LDHs hybrid beads were characterized by FTIR, XRD, and SEM to study their structure and the role that LDHs play. Swelling behaviors in various aqueous solutions and drug loading as well as controlled release behavior of the SA/LDHs hybrid beads were also investigated by using diclofenac sodium (DS) as the model drug to reveal the effects of introduced LDHs. The results indicate that the positively charged LDHs layers are adsorbed on the negatively charged SA polymer chains through electrostatic interaction and act as inorganic crosslinkers in the three-dimensional network. In addition, a small part of DS molecules intercalate into layers of LDHs through an anion exchange process. The electrostatic interaction between LDHs and SA has restricted movability of the SA polymer chains, and then slows down swelling and dissolution rates of the SA/LDHs hybrid beads in aqueous solutions. The electrostatic interaction and the intercalation of DS into layers of LDHs have also improved the entrapment efficiency (EE) and controlled release behavior of SA/LDHs hybrid beads for DS. |
| Keyword | Controlled Release Hydrogel In Vitro Smart Materials |
| Subject Area | 药物释放 |
| Funding Organization | 中科院院长奖获得者科研启动专项(2008-06) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/116 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | 王爱勤 aqwang@licp.cas.cn |
| Recommended Citation GB/T 7714 | Zhang JP,Wang Q,Xie XL,et al. Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium[J]. Journal of Biomedical Materials Research: Part B -Applied Biomaterials,2010,92(1):205-214. |
| APA | 张俊平,汪琴,谢小玲,李迅,王爱勤,&王爱勤 aqwang@licp.cas.cn.(2010).Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium.Journal of Biomedical Materials Research: Part B -Applied Biomaterials,92(1),205-214. |
| MLA | 张俊平,et al."Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium".Journal of Biomedical Materials Research: Part B -Applied Biomaterials 92.1(2010):205-214. |
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| 2010921205214.pdf（901KB） | 开放获取 | License | View Application Full Text | |||
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