| In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices | |
| Department | 环境材料与生态化学研究发展中心 |
Zhang JP(张俊平) ; Wang Q(汪琴); Wang AQ(王爱勤); 王爱勤 aqwang@licp.cas.cn
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| 2010 | |
| Source Publication | Acta Biomaterialia
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| ISSN | 1742-7061 |
| Volume | 6Issue:2Pages:445-454 |
| Abstract | In order to find a new way to slow down the release of drugs and to solve the burst release problem of drugs from traditionally used hydrogel matrices, a series of novel pH-sensitive sodium alginate/hydroxyapatite (SA/HA) nanocomposite beads was prepared by the in situ generation of HA micro-particles in the beads during the sol–gel transition process of SA. The SA/HA nanocomposites were characterized by Fourier transform IR spectroscopy, X-ray fluorescence spectrometry, scanning electron microscopy and field emission SEM in order to reveal their composition and surface morphology as well as the role that the in situ generated HA micro-particles play. The factors influencing the swelling behavior, drug loading and controlled release behavior of the SA/HA nanocomposite beads were also investigated using diclofenac sodium (DS) as the model drug. The HA micro-particles act as inorganic crosslinkers in the nanocomposites, which could contract and restrict the movability of the SA polymer chains, and then change the surface morphology and decrease the swell ratio. Meanwhile, the entrapment efficiency of DS was improved, and the burst release of DS was overcome. The factors (including concentration of Ca2+, reaction time and temperature) affecting the growth of HA micro-particles have a clear influence on the entrapment efficiency and release rate of DS. In this work, the nanocomposite beads prepared under optimum condition could prolong the release of DS for 8 h more compared with the pristine SA hydrogel beads. |
| Keyword | In Situ Hydroxyapatite Nanocomposite Controlled Release |
| Subject Area | 药物释放 |
| Funding Organization | 中科院西部行动项目(KGCX2-YW-501) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/115 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | 王爱勤 aqwang@licp.cas.cn |
| Recommended Citation GB/T 7714 | Zhang JP,Wang Q,Wang AQ,et al. In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices[J]. Acta Biomaterialia,2010,6(2):445-454. |
| APA | 张俊平,汪琴,王爱勤,&王爱勤 aqwang@licp.cas.cn.(2010).In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices.Acta Biomaterialia,6(2),445-454. |
| MLA | 张俊平,et al."In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices".Acta Biomaterialia 6.2(2010):445-454. |
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| 201062445454.pdf（1074KB） | 开放获取 | License | View Application Full Text | |||
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